GC-MS analysis and hypoglycemic properties of methanolic leaf extract of Cnidoscolus aconitifolius onalloxan-induced diabetic Wistar rats

Authors

  • Ezenwa Kelvin Iheanacho Department of Chemistry, College of Physical and Applied Sciences, Michael Okpara university of Agriculture Umudike, Nigeria
  • Okenwa Uchenna Igwe Department of Chemistry, College of Physical and Applied Sciences, Micheal Okpara University of Agriculture Umudike, Nigeria
  • Princewill Ezenwa Ndubueze Onyemachi Department of Community Medicine, College of Medical Sciences, Abia State University Teaching Hospital Aba, Nigeria

Keywords:

Chloropropamide, Anti-diabetic, Cnidoscolus aconitifolius

Abstract

The GC-MS analysis and hypoglycemic properties of methanolic leaf extract of Cnidoscolus aconitifolius were carried out on alloxan-induced diabetic Wistar rats. The GC-MS results revealed the presence of thirty-seven compounds consisting of hydrocarbons, alcohols, phenols, carboxylic acid esters, aldehydes, esters, fatty acids, and nitriles with some of them having known biological properties. The hypoglycemic properties of the methanolic leaf extract of Cnidoscolus aconitifolius were accessed by treating groups 3, 4, and 5 diabetic rats with 100, 150, and 200 mg/kg bw respectively of plant extract. Group 1 (negative control group) received only distilled water while group 2 (positive control group) was treated with 10 mg/kg bw of chloropropamide, a known anti-diabetic drug. A significant decrease in blood glucose levels was observed for groups treated with plant extract as compared to groups treated with chloropropamide. From the result obtained, the plant, Cnidoscolus aconitifolius could be used by diabetic patients to control blood glucose levels. 

Dimensions

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Hypoglycemic effects of the crude methanol extract of the leaf extracts of Cnidoscolus Aconitifolius on wistar Albino Rat.

Published

2023-12-07

How to Cite

GC-MS analysis and hypoglycemic properties of methanolic leaf extract of Cnidoscolus aconitifolius onalloxan-induced diabetic Wistar rats. (2023). African Scientific Reports, 2(3), 150. https://doi.org/10.46481/asr.2023.2.3.150

Issue

Volume 2, Issue 3, December 2023

Section

Original Research
Copyright & Licensing

Copyright (c) 2023 Kelvin Iheanacho Ezenwa, Uchenna Igwe Okenwa, Princewill Ndubueze Onyemachi Ezenwa

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

GC-MS analysis and hypoglycemic properties of methanolic leaf extract of Cnidoscolus aconitifolius onalloxan-induced diabetic Wistar rats. (2023). African Scientific Reports, 2(3), 150. https://doi.org/10.46481/asr.2023.2.3.150