Natural Skin Whitening Compounds: Types, Source and Mechanism of Action: A Review

Authors

  • Chiagoziem Wisdom Chidiebere Surface Chemistry and Environmental Technology(SCENT) Research Unit , Department of Chemistry, Imo State University, Owerri, Imo State , Nigeria
  • Ugochukwu Aniefuna Azuka Anthonia Department of Pure and Industrial Chemistry, Nnamdi Azikiwe University Awka, Nigeria

Keywords:

Skin whitening, Bleaching, Melanin, Melanogenesis

Abstract

Skin whitening, also known as skin lightening or skin bleaching, is utilizing chemical compounds to lighten or even out the skin’s colour by lowering the skin’s melanin concentration. The biosynthetic process of melanogenesis and the related main regulatory signaling pathways are summarized in this paper. It also addresses the efficacy of natural skin-whitening treatments based on their mode of action on melanogenesis and their compound classification. The review’s goal is to provide useful information and create awareness on the effects of bleaching cream.

Dimensions

S. N. Bukhari, J. Ibrahim, U. T. Oya, S. Muhammad, M. Naeem & H. L. Qin, “Biological activity and molecular docking studies of curcuminrelated alpha, beta -unsaturated carbonyl-based synthetic compounds as anticancer agents and mushroom tyrosinase inhibitors”, Journal of agricultural and food chemistry 62 (2014) 5538.

Y. Sheng, X. Jing, J. L. Lu, J. H. Ye, Z. J. Chen, J. W. Zhao, Y. R. Liang & X. Q. Zheng, “Protective e ects of gallocatechin gallate against ultraviolet B induced skin damages in hairless mice”, Scientific Reports 12 (2022) 1.

R. Mustarichi, J. Levita & D. Febriani, “In-silico study of curcumin, demethoxycurcumin, and xanthorrizol as skin whitening agents”, World Journal of Pharmaceutical Sciences 1 (2013) 72.

P. Manish, K. P. Mrunmaya & T. Hrudayanath, “Developing Hispolon-based novel anticancer therapeutics against human (NF-kapabeta ) using in silico approach of modelling, docking and protein dynamics”, Journal of Biomolecular Structure and Dynamics 23 (2018) 200.

D. Rupsa, M. H. Ti any, J. T. Sharick, A. A. Gillette & M. C. Skala, “Fluorescence lifetime imaging microscopy: fundamentals and advances in instrumentation, analysis, and applications”, Journal of biomedical optics 25 (2020) 071.

C. A. Dehelean, I. Marcovici, S. Codruta, M. Marius, D. Coricovac, S. Iurciuc, M. Octavian & L. Pinzaru, “Plant-derived anticancer compounds as new perspectives in drug discovery and alternative therapy”, Molecules 26 (2021) 1109.

B. S. Madhura & T. Tewin, “The protective effect of some Thai plants and their bioactive compounds in UV light-induced skin carcinogenesis”, Journal of Photochemistry and Photobiology B: Biology 185 (2018) 80.

L. Carmen, “Purification and biological activity of oregonin, a novel bioactive diarylheptanoid found in the leaves and bark of Alnus rubra (red alder)”, University of Victoria 23 (2017) 12.

J. O. Faronbi, O. O. Oyediran, M. A. Adebiyi, S. C. Adereti, G. O. Faronbi & T. T. Famakinwa,” Perceived risk and consequences of bleaching practices among university students in Southwest Nigeria”, International Journal of Basic, Applied and Innovative Research 7 (2018) 1.

C. Arghya, A. R. Gulzar, A. Ali, A. B. Basharat, S. S. Sankar, N. Abhishek & A. Nanda, “Nano approach: Indian spices as antimicrobial nagents”, Ethno pharmacological investigation of Indian spices 205 (2020) 241.

T. S. Chang, “An updated review of tyrosinase inhibitors”, Int. J. Mol. Sci. 10 (2009) 2440.

J. Sharifi-Rad, Y. E. Rayess, A. A. Rizk, C. Sadaka, R. Zgheib, W. Zam, S. Sestito, S. Rapposelli, K. Neffe-Skoci´nska & D. Zieli´nska, “Turmeric and its major compound curcumin on health: Bioactive effects and safety profiles for food, pharmaceutical, biotechnological and medicinal applications”, Front. Pharmacol. 11 (2020) 01021.

K. Jakubczyk, A. Druzga, J. Katarzyna & K. Skonieczna-Zydecka, “Antioxidant potential of curcumin–A meta-analysis of randomized clinical trials'', Antioxidants 9 (2020) 1092.

K. H. Lee, F. H. Aziz, A. Syahida, F. Abas, K. Shaari, D. A. Israf & N. H. Lajis, “Synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities”, Eur. J. Med. Chem. 44 (2009) 3195.

M. A. Tomeh, R. Hadianamrei & X. Zhao, “A review of curcumin and its derivatives as anticancer agents”, Int. J. Mol. Sci. 20 (2019) 1033.

D. Zheng, C. Huang, H. Huang, Y. Zhao, M. R. U. Khan, H. Zhao & L. Huang, “Antibacterial mechanism of curcumin: A review”, Chem. Biodivers. 17 (2020) e2000171.

A. Adamczak, M. Ozarowski & T. M. Karpin´ ski, “Curcumin, a natural antimicrobial agent with strain-specific activity”, Pharmaceuticals 13 (2020) 153.

M. R. Jennings & R. J. Parks, “Curcumin as an antiviral agent”, Viruses 12 (2020) 1242.

S. Nistico, F. Tamburi, L. Bennardo, S. Dastoli, G. Schipani, G. Caro, M. C. Fortuna & A. Rossi, “Treatment of telogen effluvium using a dietary supplement containing Boswellia serrata, Curcuma longa, and Vitis vinifera: Results of an observational study”, Dermatol. Ther. 32 (2019) e12842.

L. Vollono, M. Falconi, R. Gaziano, F. Iacovelli, E. Dika, C. Terracciano, L. Bianchi&E. Campione, “Potential of curcumin in skin disorders”, Nutrients 11 (2019) 2169.

C. E. Duru, I. A. Duru & C. W. Chidiebere, “Virtual screening of selected natural products as humantyrosinase-related protein 1 blocker”, J. Niger. Soc. Phys. Sci. 3 (2021) 154.

Y. Panahi, O. Fazlolahzadeh, S. L. Atkin, M. Majeed, A. E. Butler, T. P. Johnston & A. Sahebkar, “Evidence of curcumin and curcumin analogue effects in skin diseases: A narrative review”, J. Cell Physiol. 234 (2019) 1165.

Z. Y. Du, Y. F. Jiang, Z. K. Tang, R. Q. Mo, G. H. Xue, Y. J. Lu, X. Zheng, C. Z. Dong & K. Zhang, “Antioxidant and tyrosinase inhibition of polyphenolic curcumin analogs”, Biosci. Biotechnol. Biochem. 75 (2011) 2351.

K. S. Bhullar, A. Jha, D. Youssef & H. P. V. Rupasinghe, “Curcumin and its carbocyclic analogs: Structure-activity in relation to antioxidant and selected biological properties”, Molecules 18 (2013) 5389.

Y. Jiang, Z. Du, G. Xue, Q. Chen, Y. Lu, X. Zheng, A. H. Conney & K. Zhang, “Synthesis and biological evaluation of unsymmetrical curcumin analogues as tyrosinase inhibitors”, Molecules 18 (2013) 3948.

S. N. Bukhari, I. Jantan, O. Unsal Tan, M. Sher, M. Naeem-ul-Hassan & H. L. Qin, “Biological activity and molecular docking studies of curcumin-related-unsaturated carbonyl-based synthetic compounds as anticancer agents and mushroom tyrosinase inhibitors”, J. Agric. Food Chem. 62 (2014) 5538.

S. Shirota, K. Miyazaki, R. Aiyama, M. Ichioka & T. Yokokura, “Tyrosinase inhibitors from crude drugs”, Biol. Pharm. Bull. 17 (1994) 266.

Published

2023-04-29

How to Cite

Natural Skin Whitening Compounds: Types, Source and Mechanism of Action: A Review. (2023). African Scientific Reports, 2(1), 95. https://doi.org/10.46481/asr.2023.2.1.95

Issue

Volume 2, Issue 1, April 2023

Section

Review Article
Copyright & Licensing

Copyright (c) 2023 Chiagoziem Wisdom Chidiebere, Ugochukwu Aniefuna Azuka Anthonia

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

Natural Skin Whitening Compounds: Types, Source and Mechanism of Action: A Review. (2023). African Scientific Reports, 2(1), 95. https://doi.org/10.46481/asr.2023.2.1.95